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Projects Using Biospecimens

Persistent organic pollutants and breast cancer risk: chemicals old and new

Persistent organic pollutants (POPs) are chemicals that the United States banned in the 1970s due to potential health dangers. However, because these chemicals do not naturally degrade, exposure to POPs continues decades later. Polybrominated diphenyl ethers (PBDEs)—also known as ‘newer POPs’—are flame retardants that may also affect human health. This study uses biospecimens donated by California Teachers Study participants to evaluate the risk of breast cancer associated with levels of POPs seen in study blood samples.

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Germline and tumor genomic analyses of breast cancer in Latinas

Whole-exome sequencing—a technique for sequencing all the expressed genes in the genome—provides the opportunity to discover rare mutations in genes that may be associated with breast cancer susceptibility. While Latinos represent the largest and fastest-growing minority population in the United States, their genetic susceptibility to breast cancer has been largely under-studied. This study will examine breast cancer susceptibility genes in Latinas by identifying a set of genes that are significantly associated with breast cancer in Latinas.

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Menopausal transition - A window of susceptibility for the promotion of breast cancer by environmental exposures

This study explores the menopausal transition as a window of susceptibility for environmental exposures exposure. The menopausal transition begins when ovarian function begins to decline and ends at menopause when ovarian function ceases, which results in low levels of estrogens. Using biospecimens collected from CTS participants, this study is evaluating the role of environmental disrupting chemicals (EDCs)—individually and combined—in the development of breast cancer during menopausal transition.

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Biomedical Research Center, Cubicle 2016.04

1218 S. Fifth Ave.

Monrovia, California 91016

calteachersstudy@coh.org

(800) 568-9471

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